He polled 397 against Fredrick Amoah Kyei who got 136.
The election was keenly contested as supporters of the two candidates rallied support for their preferred choice.
Charles Opoku is set to face the National Democratic Congress James Gyakye Quayson ahead of June 27 by elections.
National Executives of the Party lead by General Secretary Justine Koduah Frimpong threw their support behind the winner.
Some party supporters of James Gyakye Quayson who spoke to campaigneronline.com say they are hopeful he will emerge victorious on June 27.